Large Hypertransmission Defects Exhibit Choriocapillaris Flow Speed Impairment in Nonexudative Age-Related Macular Degeneration

Ophthalmology Science 2026 Open access

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Authors: Yunchan Hwang, Muhammad Usman Jamil, Kwang Min Woo, Stephanie Kaiser, Fatima Babiker, Philip J. Rosenfeld, Nadia K. Waheed, James G. Fujimoto
DOI: 10.1016/j.xops.2025.101060
Cited by: 2
References: 65

Abstract

Purpose: To investigate choriocapillaris (CC) blood flow speed in regions associated with hypertransmission defects (hyperTDs) in nonexudative age-related macular degeneration (AMD) using variable interscan time analysis (VISTA) OCT angiography (OCTA). Design: Retrospective cross-sectional analysis of a prospectively collected cohort. Subjects: Thirty-one eyes from 29 subjects with nonexudative AMD. Methods: Patients with age-related macular degeneration were imaged using a 600 kHz A-scan rate prototype swept-source OCT with a 5 × 5 mm field of view and 5 B-scan repeats (1.25 ms interscan time). Hypertransmission defects were traced on choroidal en face projections and categorized by their greatest linear dimension (GLD): large (≥250 μm), medium (63-250 μm), and small (

Fields of Study & Subjects

Retinal Diseases and Treatments Ophthalmology and Visual Impairment Studies Retinal Imaging and Analysis

Publication details

Journal / source
Ophthalmology Science
Publisher
Elsevier BV
Volume
6
Issue
3
Pages
101060–101060
Publication date
5 January 2026
Language
EN