Assessing Polypoidal Choroidal Vasculopathy-Related OCT Features in the TENAYA and LUCERNE Trials

Objective: To describe OCT features associated with polypoidal choroidal vasculopathy (PCV) in the TENAYA and LUCERNE clinical trial cohorts. Design: Imaging analysis within 2 multinational, double-masked, randomized controlled phase III trials. Subjects: Participants with treatment-naïve neovascular age-related macular degeneration enrolled in TENAYA and LUCERNE with baseline OCT and in a subset, baseline indocyanine green angiography (ICGA). Methods: Previously described OCT features associated with PCV were evaluated among 1329 participants. Two major OCT features were evaluated (sharp-peaked pigment epithelial detachment [SPED] and sub-retinal pigment epithelium ring-like lesion) to determine the occurrence of OCT-defined PCV. Subretinal fluid, intraretinal fluid (IRF), and hyperreflective material (HRM), were compared between OCT-defined PCV and non-PCV eyes. A sensitivity analysis was performed in the subset of eyes with available ICGA to assess concordance between OCT and ICGA-confirmed PCV. Main Outcome Measures: Occurrence of OCT-defined PCV and distribution of OCT-based disease activity biomarkers by PCV status. Results: < 0.001). In the ICGA subset (n = 274), the combination of SPED and ring demonstrated good sensitivity (85.2%) and high specificity (98.8%) relative to ICGA. Conclusions: Using 2 Asia-Pacific Ocular Imaging Society major OCT features, OCT-based diagnostic strategy may help triage or screen for PCV when ICGA is unavailable. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.