Molecular and spatial differences in the tumor microenvironment of high-grade serous ovarian cancers with short versus long-term survival

Gynecologic Oncology 2026 Open access

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Authors: Alexandra H. Smick, Natalia Zurek, Barbie Taylor‐Harding, Beth Y. Karlan, Ann E. Walts, Arkadiusz Gertych, Sandra Oršulić
DOI: 10.1016/j.ygyno.2026.05.017
Cited by: 1
References: 32

Abstract

OBJECTIVE: Survival of patients diagnosed with advanced-stage high-grade serous ovarian cancer (HGSOC) varies widely. Understanding the biological and molecular differences between tumors associated with short-term and long-term survival may inform prognosis and treatment. METHODS: Omental tumor samples were collected from 15 short-term survivors (STS;

Fields of Study & Subjects

Ovarian cancer diagnosis and treatment PARP inhibition in cancer therapy Biomarkers in Disease Mechanisms

Publication details

Journal / source
Gynecologic Oncology
Publisher
Elsevier BV
Volume
210
Pages
55–62
Publication date
23 May 2026
Language
EN