Spatial Transcriptomic Signatures of Cardiac Sarcoidosis

Journal of Cardiac Failure - Intersections 2026 Open access

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Authors: Yee Hoon Foong, ARUSHI SINGH, MARIA MALIK, Fang Zhou, Cindy Lin Liu, David K Willett, David Golombeck, Tatiana Zuluaga, Hortense Le, Avrom S. Caplan, José Gabriel Barcia Durán, Glenn I. Fishman
+5 more Anthony Aizer, Alex Reyentovich, Eliot G. Peyster, Randal I. Goldberg, Rami Sesha Vanguri
DOI: 10.1016/j.yjcafi.2025.12.009
Cited by: 0
References: 7

Abstract

Cardiac sarcoidosis (CS) is characterized by patchy granulomatous myocardial inflammation, which can lead to conduction abnormalities, arrhythmias, heart failure, and sudden cardiac death. The gold standard for diagnosis is histological confirmation of noncaseating granulomas on endomyocardial biopsy (EMB), which has limited sensitivity (20-30% yield) due to focal myocardial involvement, resulting in frequent false negatives [1]. Diagnosis often relies on multimodal approaches integrating clinical and imaging criteria.

Fields of Study & Subjects

Sarcoidosis and Beryllium Toxicity Research Eosinophilic Disorders and Syndromes Histiocytic Disorders and Treatments

Publication details

Journal / source
Journal of Cardiac Failure - Intersections
Volume
2
Issue
3
Pages
278–283
Publication date
2 January 2026
Language
EN