Implications of Exercise Wedge Pressure in Heart Failure With Preserved Ejection Fraction Identified by Pressure-Flow Slopes

Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome that is associated with multiple comorbidities1. Due to overlapping symptoms with obesity, chronic lung disease, and atrial arrhythmias, HFpEF is often mischaracterized or underdiagnosed2,3. It has become increasingly recognized that patients with HFpEF may have normal hemodynamics at rest but develop abnormal filling pressures during provocation. Exercise right heart catheterization (RHC) serves as the gold standard for diagnosing HFpEF during these situations4.