AFP-specific T cell receptors with fine-tuning affinity induce durable tumor remission in mice and acquire pan-HLA-A∗02 recognition

Cheng Huang; Jiajia Du; J. Li; Ya-Hao Guo; Qingjia Yan; Sha Wu; Xihe Chen; Tein Foong Leong; Siyun Chen; An-Da Zheng; Shudan Ou; Minjun Ma; Chunguang Yang; Lulu Zhang; Xiangjun Zhou; Junjun Chu; Yanyan Han

doi:10.1016/j.ymthe.2026.01.026

AFP-specific T cell receptors with fine-tuning affinity induce durable tumor remission in mice and acquire pan-HLA-A∗02 recognition

Molecular Therapy 2026 Open access

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Authors: Cheng Huang, Jiajia Du, J. Li, Ya-Hao Guo, Qingjia Yan, Sha Wu, Xihe Chen, Tein Foong Leong, Siyun Chen, An-Da Zheng, Shudan Ou, Minjun Ma

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Chunguang Yang, Lulu Zhang, Xiangjun Zhou, Junjun Chu, Yanyan Han

DOI: 10.1016/j.ymthe.2026.01.026

Cited by: 1

References: 34

Fields of Study & Subjects

CAR-T cell therapy research Immunotherapy and Immune Responses Monoclonal and Polyclonal Antibodies Research

Publication details

Journal / source: Molecular Therapy
Publisher: Elsevier BV
Volume: 34
Issue: 5
Pages: 2666–2677
Publication date: 23 January 2026
Language: EN

References 34