Chemogenetic modulation of CNS pericytes: Impact on pericyte Ca2+ dynamics, CBF, BBB, and Alzheimer’s disease progression in mice
Abstract
transients but leads to a significant increase in local RBCv. Chronic activation of pericyte Gi signaling for 30 days in adult 5xFAD mice exacerbated Aβ accumulation, enhanced microglial activation, and worsened working and spatial memory and learning deficits. Conversely, chronic activation of Gq signaling in adult 5xFAD mice reduced Aβ deposition, decreased microglial activation, and improved spatial learning. These findings suggest that systemic inhibition of CNS pericytes could be a promising therapeutic strategy for slowing AD progression by preserving BBB integrity, increasing CBF, and reducing neuroinflammation.
Fields of Study & Subjects
Barrier Structure and Function Studies
Cerebrospinal fluid and hydrocephalus
Alzheimer's disease research and treatments
Publication details
- Journal / source
- Molecular Therapy
- Publisher
- Elsevier BV
- Volume
- 34
- Issue
- 5
- Pages
- 2906–2922
- Publication date
- 3 February 2026
- Language
- EN