T cell senescence induced by DNMT1 deletion mediates cardiac transplant tolerance via altered CDKN1A methylation

Molecular Therapy 2026 Open access

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Authors: Y. Chen, Wai Yen Yim, Chenghao Li, Zihao Wang, Jun Hou, Yongbu Peng, Fayuan Liu, Zongtao Liu, Nianguo Dong, Yixuan Wang
DOI: 10.1016/j.ymthe.2026.02.015
Cited by: 4
References: 53

Abstract

T cell senescence by altering CDKN1A methylation, thereby reducing T cell function and mitigating rejection. DNMT1 may thus serve as a potential therapeutic target for heart transplant rejection.

Fields of Study & Subjects

Congenital heart defects research Epigenetics and DNA Methylation Cancer-related Molecular Pathways

Publication details

Journal / source
Molecular Therapy
Publisher
Elsevier BV
Volume
34
Issue
6
Pages
3484–3502
Publication date
14 February 2026
Language
EN