An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model

Molecular Therapy 2026 Open access

Read full text
Authors: Mattia Fumagalli, Dongjie An, Luca Simula, Camille Combe, Lisa Aziez, Yannick Simoni, Marie-Clotilde Alves-Guerra, Andrea Valentini, Maude Marchais, Anaïs Vermare, Josquin Moraly, Simona Manni
+6 more Maria Cecilia Quadraccia, Concetta Quintarelli, Biagio De Angelis, Nadège Bercovici, Emmanuel Donnadieu, Frédéric Pendino
DOI: 10.1016/j.ymthe.2026.04.009
Cited by: 3
References: 97

Fields of Study & Subjects

CAR-T cell therapy research CRISPR and Genetic Engineering Virus-based gene therapy research

Publication details

Journal / source
Molecular Therapy
Publisher
Elsevier BV
Volume
34
Issue
7
Pages
3976–4000
Publication date
4 April 2026
Language
EN