Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial

The Lancet 2026 Open access

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Authors: Joseph P Broderick, Andrew Naidech, Jordan J Elm, Kazunori Toyoda, Dar Dowlatshahi, Andrew M Demchuk, Pooja Khatri, Thorsten Steiner, Philip M Bath, Heinrich J Audebert, Achala Vagal, Sohei YOSHIMURA
+88 more Stephan A Mayer, Lily L Wang, Noor Sabagha, J D Mocco, Carlos Molina, Richard Aviv, Emily Stinson, Syed A. Quadri, Janice Carrozzella, Thien Huynh, Anh Phan, Jonathan Beall, Iris Davis, Nobuyuki Sakai, Tsuyoshi Ohta, Michiko Yokosawa, Takayuki Hara, Navdeep Sangha, Kenichi Morita, Ming Yin Dominc Tse, Christopher Streib, Fumio Miyashita, Yolanda Silva, Yoshinari Nagakane, Tudor Gheorghiu, Chung‐Huan Sun, Teruyuki Hirano, Sven Poli, Tsuyoshi Izumo, Mayumi Fukuda-Doi, Masafumi Ihara, Masatoshi Koga, Brian Buck, Kyle B Walsh, Ilana Spokovny, James C Grotta, Joseph P Broderick, James Grotta, Andrew Naidech, Jordan J Elm, Kazunori Toyoda, Andrew M Demchuk, Dar Dowlatshahi, Carlos Molina, Thorsten Steiner, Philip Bath, Heinrich J Audebert, Jay Mocco, Pooja Khatri, Achala Vagal, Richard Aviv, Stephan A Mayer, Scott Janis, Sohei YOSHIMURA, Syed A. Quadri, Emily Stinson, Noor Sabagha, Lily L Wang, Janice Carrozzella, Thien Huynh, Anh Phan, Jonathan Beall, Iris Davis, Nobuyuki Sakai, Tsuyoshi Ohta, Michiko Yokosawa, Takayuki Hara, Navdeep Sangha, Kenichi Morita, Ming Yin Dominic Tse, Christopher Streib, Fumio Miyashita, Yolanda Silva, Yoshinari Nagakane, Tudor Gheorghiu, Chung‐Huan Sun, Teruyuki Hirano, Sven Poli, Tsuyoshi Izumo, Mayumi Fukuda-Doi, Masafumi Ihara, Masatoshi Koga, Brian Buck, Kyle B Walsh, Ilana Spokoyny, Digvijaya Navalkele, Toshiyuki Fujinaka, Joan Marti Fabregas
DOI: 10.1016/s0140-6736(26)00097-8
Cited by: 7
References: 37

Fields of Study & Subjects

Intracerebral and Subarachnoid Hemorrhage Research Blood properties and coagulation Trauma Hemostasis Coagulopathy Resuscitation

Publication details

Journal / source
The Lancet
Publisher
Elsevier BV
Volume
407
Issue
10530
Pages
773–783
Publication date
1 February 2026
Language
EN