Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial

The Lancet 2026

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Authors: Julio Rosenstock, Julio Rosenstock, Daisuke Yabe, David A. Cox, Jianghao Li, Max Denning, Wen-Shuo Wu, Rong Liu, Youna Zhao, Federico Pérez Manghi, Franklin Ábalos, P. Costanzo
+88 more Ana Chiesa, Natacha Maldonado, Susana Salzberg, Claudia Goycoa, Horacio Sessa, Diego Aizenberg, Marisa L. Vico, Fernando Guerlloy, María Schiavoni, Mariano I. Chahin, Adriana Villarino, Ines Bartolacci, Adrian Hernandez Gauna, Marcos Mayer, Shunbin Li, Zhenmei An, Jianhua Ma, Shu Li, Jian Zhou, Guoyue Yuan, YIBING LU, Hongman Wang, Qingju Li, Xinyu Li, Tian Feng Wu, Xiaozhen Jiang, Yawei Zhang, Yufeng Li, Hong Zhu, Yihua Wang, Hongwei Jiang, Jie Shen, XIAOLIN DONG, ZhiFeng Cheng, Tetsuji Niiya, Shinya Nakamoto, NOBUYUKI SATO, Masahiko Takai, T. Kato, Toshihiko Shiraiwa, Hidenori Bando, Akira Ohishi, Takeshi Osonoi, Melchor Alpizar Salazar, Pedro Garcia Hernandez, Elías Alberto García Cantú, Manuel de los Rios Ibarra, Emilia Pelayo Orozco, Maria Arechavaleta Granell, José Lazcano Soto, Luis Virgen Carrillo, Laura Castro Castrezana, Silvia Ramos, Arnulfo Gonzalez, Carlos Alejandro Stobschinski de Alba, Ramiro Banda Elizondo, Raymundo García Reza, Jose Gerardo Gonzalez Gonzalez, Jose Gerardo Gonzalez Gonzalez, Yshay Shlesinger, Jawad Sarwar, Sumana Gangi, Bram Wieskopf, Thaidra Gaufin, Rachel Anderson, Eric Garcia-Torres, Eduardo Luna, Peter Philander, Christopher Chow, Sridhar Guduri, Alex Gonzalez-Bossolo, Brock McConnehey, Lisa S. Usdan, Donald Brautigam, Martha Gomez-Cuellar, Michael Adams, Alison Schneider, Dennis Tsang, Peter Mattar, Talessa Powell, Paola Mansilla-Letelier, Lisa Connery, Reynaldo Lopez, Robert Buynak, Damaris Vega, Juan Loy, Herbert Conaway, James Schultz
DOI: 10.1016/s0140-6736(26)00202-3
Cited by: 24
References: 24

Fields of Study & Subjects

Diabetes Treatment and Management Diabetes Cardiovascular Risks and Lipoproteins Hyperglycemia and glycemic control in critically ill and hospitalized patients

Publication details

Journal / source
The Lancet
Publisher
Elsevier BV
Volume
407
Issue
10534
Pages
1147–1160
Publication date
26 February 2026
Language
EN