Orforglipron compared with dapagliflozin in adults with type 2 diabetes and inadequate glycaemic control with metformin (ACHIEVE-2): a multicentre, randomised, non-inferiority, open-label, phase 3 trial

The Lancet 2026

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Authors: Michelle Welch, Thomas Forst, Weiping Jia, Pedro Orozco del Pino, Max Denning, Wen-Shuo Wu, Jianghao Li, Rong Liu, MICHELE EIFU, Yanyun Chen, Brian Beesley, Jeffrey Chasteen
+71 more Jung-Fu Chen, Zhi Feng Cheng, Chern-En Chiang, Chih-Hsun Chu, Lisa Connery, Manuel de los Rios Ibarra, Xiaolin Dong, Adil Fatakia, Thomas Forst, Pedro García, Elías García, Miguel Gomez-Samano, Guillermo Gonzalez Galvez, Janusz Gumprecht, Malgorzata Jozefowska, Behnam Khaleghi, Satkirin Khalsa, John Kirby, Bastian Kirsch, Magdalena Kwiatkowska, José Lazcano Soto, Qingju Li, Tsung-Hsien Lin, Dexue Liu, Enrique López Rosas, Babette Lorra, Yibing Lu, Tomasz Ługowski, Jianhua Ma, Arash Matian, Gustavo Méndez Machado, Richard Mills, Dorota Mlodawska-Choluj, Yoko Momoyama, Piotr Napora, Horng-Yih Ou, Dee Pei, Steven Reynolds, María Elena Romero-Ibarguengoitia, Ludger Rose, Julio Rosenstock, Justen Rudolph, Leobardo Sauque Reyna, Axel Schaefer, Thomas Schaum, Alexander Segner, Bimin Shi, Katarzyna Siewko, Ewa Skokowska, Agata Smoleń, Joseph Soufer, Andreas Staudenmeyer, Ewa Szyprowska, Shehzad Topiwala, Damaris Vega, Rafael Vidal Tamayo Ramírez, Apinya Vutikullird, Chih-Yuan Wang, Jun‐Sing Wang, Katarzyna Wasilewska, Michelle Welch, Veronika Wenzl-Bauer, Jonathan Wilson, Peter Witzel, Yushan Xu, Jun Ye, Haoyong Yu, Guoyue Yuan, Eduardo Yañez Ruiz, Helga Zeller, Hong Zhu
DOI: 10.1016/s0140-6736(26)00800-7
Cited by: 1
References: 22

Fields of Study & Subjects

Diabetes Treatment and Management Diabetes Cardiovascular Risks and Lipoproteins Diabetes Management and Research

Publication details

Journal / source
The Lancet
Publisher
Elsevier BV
Volume
408
Issue
10550
Pages
125–140
Publication date
8 June 2026
Language
EN