Weight gain, body composition, and metabolic parameters of dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: an ancillary analysis of the ODYSSEY trial

The Lancet Child & Adolescent Health 2026 Open access

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Authors: Anna Turkova, Anna Turkova, Ellen White, Avy Violari, Hilda A Mujuru, Adeodata R Kekitiinwa, Abbas Lugemwa, Elizabeth Kaudha, Sathaporn Na-Rajsima, Grace M Ahimbisibwe, Ebrahim Variavae, Moherndran Archary
+88 more Yasmeen Akhalwaya, Thanyawee Puthanakit, Mutsa Bwakura-Dangarembizi, Dickson Bbuye, Mariam Kasozi, Afaaf Liberty, Christoph Königs, Steven B Welch, Yoann Riault, Alasdair Bamford, Tim R Cressey, Philippa Musoke, Cissy Kityo, Rashida Ferrand, Carlo Giaquinto, Pablo Rojo, Diana M. Gibb, Deborah Ford, Pattamukkil Abraham, Elaine Abrams, Judith Acero, Gerald Muzorah Agaba, Grace M Ahimbisibwe, Barbara Ainebyoona, Yasmeen Akhalwaya, Winnie Akobye, Nazim Akoojee, Shabinah S. Ali, Pauline Amuge, Catherine Andrea, Rogers Ankunda, Suvaporn Anugulruengkitt, Tsitsi Apollo, Moherndran Archary, Ronelle Arendze, Juliet Ategeka, Eunice Atim, Lorna Atwine, Abdel Babiker, Sarah Babirye, Enock Babu, Joanita Nankya Baddokwaya, Themelihle Bafana, Edward Bagirigomwa, Angella Baita, David Balamusani, Patsy Baliram, David Baliruno, Colin Ball, Henry Balwa, Alasdair Bamford, Srini Bandi, Dominique Barker, Linda Barlow-Mosha, Dickson Bbuye, Shazia Begum, Osee Behuhuma, Sarah Bernays, Rogers Besigye, Maria Bester, Joyline Bhiri, Davide Bilardi, Kristien Bird, Pauline Bollen, Chiara Borg, Anne-Marie Borges Da Silva, Jackie Brown, Elena Bruno, Torsak Bunupuradah, David Burger, Nomzamo Buthelezi, Mutsa Bwakura-Dangarembizi, Africanus Byaruhanga, J. Calvert, Petronelle Casey, Haseena Cassim, Sphiwee Cebekhulu, Sanuphong Chailert, Suwalai Chalermpantmetagul, Suwalai Chalermpantmetagul, Wanna Chamjamrat, Man Ho Chan, Precious Chandiwana, Thannapat Chankun, Sararut Chanthaburanun, Nuttawut Chanto, Ennie Chidziva, Minenhle Chikowore
DOI: 10.1016/s2352-4642(25)00339-6
Cited by: 2
References: 28

Abstract

BACKGROUND: ODYSSEY trial showed superior efficacy of dolutegravir-based antiretroviral therapy (ART) versus then-current, non-dolutegravir standard of care over 96 weeks in children and adolescents living with HIV. The aim of this ancillary analysis was to compare anthropometric and body composition outcomes, including weight, height, BMI-for-age Z score, weight-for-age and height-for-age Z scores (

Fields of Study & Subjects

HIV-related health complications and treatments HIV/AIDS drug development and treatment HIV/AIDS Research and Interventions

Publication details

Journal / source
The Lancet Child & Adolescent Health
Publisher
Elsevier BV
Volume
10
Issue
3
Pages
189–202
Publication date
21 January 2026
Language
EN