Efficacy of antiviral therapy in adults with chronic hepatitis B according to baseline hepatitis B virus DNA and alanine aminotransferase concentrations: a systematic review and meta-analysis

Yu Ri Im; Si Chen; Rukmini Jagdish; Daniela Yucuma; Arthur Rakover; Zakary Warsop; Roger Chou; Philippa Easterbrook; Yusuke Shimakawa

doi:10.1016/s2468-1253(25)00301-2

Efficacy of antiviral therapy in adults with chronic hepatitis B according to baseline hepatitis B virus DNA and alanine aminotransferase concentrations: a systematic review and meta-analysis

The Lancet. Gastroenterology & hepatology 2026 Open access

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Authors: Yu Ri Im, Si Chen, Rukmini Jagdish, Daniela Yucuma, Arthur Rakover, Zakary Warsop, Roger Chou, Philippa Easterbrook, Yusuke Shimakawa

DOI: 10.1016/s2468-1253(25)00301-2

Cited by: 2

References: 48

Abstract

Background In the 2015 WHO guidelines for chronic hepatitis B (CHB), antiviral therapy was recommended for individuals with cirrhosis and individuals without cirrhosis with persistently elevated alanine aminotransferase (ALT) concentrations and hepatitis B virus (HBV) DNA >20 000 IU/mL, whereas treatment was deferred for individuals with persistently normal ALT concentrations and HBV DNA

Fields of Study & Subjects

Hepatitis B Virus Studies Hepatitis C virus research Hepatitis Viruses Studies and Epidemiology

Publication details

Journal / source: The Lancet. Gastroenterology & hepatology
Publisher: Elsevier BV
Volume: 11
Issue: 5
Pages: 397–416
Publication date: 14 March 2026
Language: EN

References 48