Natural history of chronic hepatitis B in untreated adults without cirrhosis according to baseline hepatitis B virus DNA and alanine aminotransferase concentrations: a systematic review and meta-analysis

˜The œLancet. Gastroenterology & hepatology 2026 Open access

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Authors: Daniela Yucuma, Arthur Rakover, Zakary Warsop, Yu Ri Im, Si Chen, Rukmini Jagdish, Gibril Ndow, Maud Lemoine, Hailemichael Desalegn, Asgeir Johannessen, Hwai‐I Yang, Yasuhito Tanaka
+3 more Roger Chou, Philippa Easterbrook, Yusuke Shimakawa
DOI: 10.1016/s2468-1253(25)00302-4
Cited by: 2
References: 82

Abstract

BACKGROUND: Chronic hepatitis B (CHB) affects an estimated 254 million people globally. Historically, WHO and professional society guidelines have recommended treatment for individuals at high risk of disease progression, including those with hepatitis B virus (HBV) DNA concentrations >20 000 IU/mL. Whether individuals at lower risk, including those with HBV DNA

Fields of Study & Subjects

Hepatitis B Virus Studies Hepatitis C virus research Liver Disease Diagnosis and Treatment

Publication details

Journal / source
˜The œLancet. Gastroenterology & hepatology
Publisher
Elsevier BV
Volume
11
Issue
5
Pages
380–396
Publication date
14 March 2026
Language
EN