PICS in Pediatric Survivors of Critical Illness

Pediatric critical illness survival has soared in high-income countries while intensive care infrastructure is improving in lower- and middle-income countries. The framework of Post-Intensive Care Syndrome- pediatrics (PICS-p) encompasses new impairments in cognitive, emotional, physical, social, and family health of the critically ill child across the developmental span. Notably caregivers and siblings may additionally experience PICS-p as a result of their relationship with critically ill children. Single or multi-domain impairments occur in the face of pre-existing, ICU-based, and post-ICU risk factors and may be long-lasting and affect development. Prevention and treatment interventional evidence is growing but key knowledge gaps and validation trials are lacking.