Emergence of a novel genotype of extensively drug-resistant Shigella sonnei carrying blaDHA-1 in diverse patient populations, Los Angeles, 2024–2025

Antimicrobial Stewardship & Healthcare Epidemiology 2026 Open access

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Authors: Shekina Gonzalez-Ferrer, Bennett Shaw, Lilian Fung, Raphael J. Landovitz, Daniel Z. Uslan, Shangxin Yang
DOI: 10.1017/ash.2025.10280
Cited by: 4
References: 19

Abstract

Abstract Extensively drug-resistant (XDR) Shigella is a public health threat, historically linked to blaCTX-M-15 gene in sexually transmitted cases. We describe a novel XDR S. sonnei carrying an AmpC-type blaDHA-1 gene from two unrelated cases with unknown transmission route; whole-genome sequencing revealed close genetic relatedness, signaling broader community spread.

Fields of Study & Subjects

Escherichia coli research studies Antibiotic Resistance in Bacteria Viral gastroenteritis research and epidemiology

Publication details

Journal / source
Antimicrobial Stewardship & Healthcare Epidemiology
Publisher
Cambridge University Press (CUP)
Volume
6
Issue
1
Pages
e19–e19
Publication date
1 January 2026
Language
EN