Clinical utility of serial plasma cell-free DNA metagenomic next-generation sequencing assays

Infection Control and Hospital Epidemiology 2026 Open access

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Authors: Ishminder Kaur, Bennett M. Shaw, Ashrit Multani, Sanchi Malhotra, Huan Vinh Dong, Christy Lukose, Kavitha K. Prabaker, Tawny Saleh, Young Bo Sim, Christopher N. Tymchuk, Daniel Z. Uslan, Helen Zhou
+2 more Timothy F. Brewer, Shangxin Yang
DOI: 10.1017/ice.2025.10390
Cited by: 1
References: 11

Abstract

This single center retrospective observational study of serial plasma metagenomic next-generation sequencing testing shows that >95% of serial testing was without meaningful clinical impact. Only 5/173 cases were adjudicated as having significant clinical impact.

Fields of Study & Subjects

Cancer Genomics and Diagnostics Genomics and Rare Diseases Acute Myeloid Leukemia Research

Publication details

Journal / source
Infection Control and Hospital Epidemiology
Publisher
Cambridge University Press (CUP)
Volume
47
Issue
3
Pages
325–327
Publication date
13 January 2026
Language
EN