Translating Supramolecular Design Principles to Camptothecin for Precision and Targeted Cancer Therapy
Abstract
Conspectus Cancer, responsible for approximately 16.8% of global mortality, remains one of the most formidable challenges to public health. Chemotherapy remains a mainstay of cancer treatment, utilizing small-molecule agents to inhibit tumor growth, invasion, and metastasis. Camptothecin (CPT) exhibits broad-spectrum antitumor activity; however, its clinical potential is severely limited by poor aqueous solubility, low stability, and insufficient tumor selectivity, which collectively restrict its bioavailability and therapeutic efficacy. Conventional formulations such as covalent chemical modifications, lipid encapsulations and PEGylated conjugates have been developed to address these issues but often suffer from short half-lives, low drug-loading capacities (
Fields of Study & Subjects
Supramolecular Self-Assembly in Materials
Supramolecular Chemistry and Complexes
Polydiacetylene-based materials and applications
Publication details
- Journal / source
- Accounts of Materials Research
- Publisher
- American Chemical Society (ACS)
- Volume
- 7
- Issue
- 4
- Pages
- 368–381
- Publication date
- 29 January 2026
- Language
- EN