Spacer-Acceptor Synergy in Cyanide Detection: Leveraging Dual-Site Reactivity to Overcome Sensitivity-Range Trade-Offs
Abstract
The persistent trade-off between sensitivity and linear concentration range in reaction-based chemosensors remains a critical limitation for rapid analyte detection with high precision. This significantly limits the practical deployment of these reaction-based chemosensors, especially in the detection of hazardous ions such as cyanide. Addressing this challenge, we rationally developed donor−π–acceptor fluorescent probes, TRMN and TπRMN, featuring triphenylamine donors, conjugated rhodanine acceptors, and differentiated π-spacers. Concurrently, their parent aldehydes were investigated to understand their photophysical baseline, wherein the spacer rigidity suppresses the nonradiative process. Both TRMN and TπRMN exhibit rapid (
Fields of Study & Subjects
Molecular Sensors and Ion Detection
Luminescence and Fluorescent Materials
Forensic Fingerprint Detection Methods
Publication details
- Journal / source
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 98
- Issue
- 3
- Pages
- 2191–2202
- Publication date
- 15 January 2026
- Language
- EN