A Double-Shell Hollow Hf-MOF-Driven Electrochemiluminescence Strategy for the Detection of miRNA-7
Abstract
Se Schottky junction array was prepared to provide a uniform and stable electromagnetic field enhancement. Benefiting from the surface plasmonic coupling effect, the luminescence intensity of DSH Hf-MOF was enhanced 7.05 times. The DSH Hf-MOF-driven electrochemiluminescence (ECL) sensor was used for the detection of miRNA-7 with a range from 0.5 fM to 1 nM and a low detection limit of 0.15 fM. More importantly, this biosensor can effectively distinguish between glioma tumor tissues and adjacent paracancerous tissues, demonstrating clear application value in clinical pathological differentiation.
Fields of Study & Subjects
Metal-Organic Frameworks: Synthesis and Applications
Advanced biosensing and bioanalysis techniques
MicroRNA in disease regulation
Publication details
- Journal / source
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 98
- Issue
- 6
- Pages
- 5045–5053
- Publication date
- 4 February 2026
- Language
- EN