Enzyme-Activatable and Tumor-Targeted Nanosystem for Real-Time Imaging and Synergistic Zn 2+ -Interference Photothermal Therapy of Breast Cancer Bone Metastasis

Analytical Chemistry 2026

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Authors: Yujia Zhang, Chen Zhao, Jukun Yang, Qiong Wu, Pinyi Ma, Shan Jiao, Daqian Song
DOI: 10.1021/acs.analchem.6c00092
Cited by: 1
References: 42

Abstract

experiments showed that APAZPs preferentially accumulated at bone metastatic sites, and upon 808 nm irradiation, they significantly suppressed tumor growth and reduced tumor volume to 45% of the initial size without observable systemic toxicity. This activatable nanosystem is a versatile platform for real-time imaging and synergistic therapy. It is a promising tool for precision intervention in breast cancer bone metastasis.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Cancer Research and Treatment Photodynamic Therapy Research Studies

Publication details

Journal / source
Analytical Chemistry
Publisher
American Chemical Society (ACS)
Volume
98
Issue
17
Pages
12698–12707
Publication date
18 April 2026
Language
EN