Electrospray Regime Controls Sensitivity and Quantitative Performance in Micro- and Nano-Flow CE–ESI–MS

Analytical Chemistry 2026 Open access

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Authors: Ryan M O'Neal, Laura Rodríguez, Péter Nemes
DOI: 10.1021/acs.analchem.6c01323
Cited by: 6
References: 50

Abstract

embryonic samples at single-cell-scale input, CJ significantly increased the number of detected metabolite features and improved recovery of functionally annotated protein groups. These results establish ESI regime as a controllable driver of sensitivity and quantitative performance in CE-ESI-MS and provide practical guidance for selecting ionization conditions for trace-limited analyses.

Fields of Study & Subjects

Mass Spectrometry Techniques and Applications Metabolomics and Mass Spectrometry Studies Advanced Proteomics Techniques and Applications

Publication details

Journal / source
Analytical Chemistry
Publisher
American Chemical Society (ACS)
Volume
98
Issue
19
Pages
14516–14525
Publication date
2 May 2026
Language
EN