How Medically Important Antimicrobials Bind to the 30S Ribosomal Subunit in a Bacterial Pathogen

Biochemistry 2026 Open access

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Authors: Swati R. Manjari, Caleb Mallery, Nilesh K. Banavali
DOI: 10.1021/acs.biochem.6c00008
Cited by: 1
References: 48

Abstract

ribosomal 30S small subunit. For this, we used structural analogy, restrained energy minimization, and single-point binding free energy computations. We find the single-point binding free energy of the MIAs to be very sensitive to small conformational changes in the MIA and its environment. Incorporating this knowledge in structure-guided design could aid in the development of narrow-spectrum MIAs targeting specific bacterial pathogens.

Fields of Study & Subjects

RNA and protein synthesis mechanisms RNA modifications and cancer Antimicrobial Peptides and Activities

Publication details

Journal / source
Biochemistry
Publisher
American Chemical Society (ACS)
Volume
65
Issue
14
Pages
2250–2258
Publication date
30 April 2026
Language
EN