Ugi-Type Reaction Enables Access to Fused Imidazole Derivatives for DNA-Encoded Library Technology

Bioconjugate Chemistry 2026

View at publisher
Authors: Hao Guo, Zitao Li, Gaonan Wang, Biyu Zhang, Mengxue Wang, Lu Liu, Alexander L. Satz, Wenji Su, Letian Kuai, Qi Zhang
DOI: 10.1021/acs.bioconjchem.5c00655
Cited by: 2
References: 30

Abstract

This study presents a DNA-compatible synthesis of diverse N-fused imidazopyridines via a catalyst-free Ugi-type multicomponent reaction using TMSCN as a functional isonitrile equivalent. The desilylation activation occurs efficiently in water without additional catalysts. The method exhibits a broad substrate scope for aldehydes and heterocyclic amidines and excellent chemoselectivity, underscoring its utility for constructing privileged heteroaromatic scaffolds in DNA-encoded library technology.

Fields of Study & Subjects

Chemical Synthesis and Analysis Synthesis and Reactivity of Heterocycles Multicomponent Synthesis of Heterocycles

Publication details

Journal / source
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Volume
37
Issue
4
Pages
675–683
Publication date
28 March 2026
Language
EN