Crystal Structure of Ritonavir Form IV and Thermodynamic Relationships between Ritonavir Polymorphs

Crystal Growth & Design 2026

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Authors: Stephan D. Parent, Jared P. Smit, Dale K. Purcell, Pamela A. Smith, Pierre Le Maguerès, Haley Bauser, Adrian Radocea
DOI: 10.1021/acs.cgd.5c01571
Cited by: 3
References: 26

Abstract

The crystal structure of Ritonavir Form IV is reported. The structure was determined by electron diffraction, and the molecular conformation and hydrogen bonding show similarities to those of Forms I and III. Form II is shown to be the most thermodynamically stable of the four known polymorphs.

Fields of Study & Subjects

Inorganic Fluorides and Related Compounds HIV/AIDS drug development and treatment Crystallography and molecular interactions

Publication details

Journal / source
Crystal Growth & Design
Publisher
American Chemical Society (ACS)
Volume
26
Issue
3
Pages
1386–1392
Publication date
23 January 2026
Language
EN