Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders
Abstract
assays and provide a concise framework for prioritizing and mapping them to decision stages. We also discuss the main factors affecting degrader's cellular performance and principles that have emerged to guide drug design.
Fields of Study & Subjects
Biotin and Related Studies
Protein purification and stability
Protein Structure and Dynamics
Publication details
- Journal / source
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Volume
- 126
- Issue
- 10
- Pages
- 5755–5791
- Publication date
- 14 May 2026
- Language
- EN