The Shape of Things to Come: α-Helical Membrane Protein Folding on the Ribosome

Chemical Reviews 2026 Open access

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Authors: Edward Lambden, Benjamin Russell Lewis, Zadie L. R. Baker, Marvin V. Dilworth, Erin C Johnston, Juan Palacios-Ortega, Kaylee Patel, Colin P. Pilkington, Heather E. Findlay, Paula J. Booth, Grant A. Pellowe
DOI: 10.1021/acs.chemrev.6c00236
Cited by: 1
References: 408

Abstract

membrane protein folding. The mechanisms driving membrane protein folding remain elusive, largely due to the limited availability of approaches that can probe these processes both in real-time and in their native context. Here, we discuss recent progress in uncovering how membrane proteins fold during synthesis and insertion, and highlight how established and emerging biophysical and structural tools are beginning to resolve cotranslational events with greater mechanistic detail than has been previously possible. Together, these advances are reshaping our understanding of membrane protein biogenesis far beyond traditional refolding models.

Fields of Study & Subjects

Bacterial Genetics and Biotechnology RNA and protein synthesis mechanisms Lipid Membrane Structure and Behavior

Publication details

Journal / source
Chemical Reviews
Publisher
American Chemical Society (ACS)
Volume
126
Issue
12
Pages
7303–7337
Publication date
18 May 2026
Language
EN