Maternal Heat Shock Protein as a Potential Biomarker of Adaptation to Heat Stress during Pregnancy and Its Relation to Preterm Birth

Environmental Science & Technology 2026 Open access

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Authors: Xiaoran Yang, Yuhong Hu, Noelle Pardo, Yan Xu, Roxana Khalili, Aviva Wolf-Jacobs, Sandrah P Eckel, Zhongzheng Niu, Tingyu Yang, Xinci Chen, Helen Foley, Danilo Guardado
+9 more Brendan Grubbs, Laila Al-Marayati, Claudia M Toledo-Corral, Jill Johnston, Genevieve Fridlund Dunton, Shohreh F. Farzan, Theresa M. Bastain, Rima Habre, Carrie V. Breton
DOI: 10.1021/acs.est.5c14632
Cited by: 1
References: 45

Abstract

We evaluated whether maternal HSP27 and HSP70 responded to heat stress during pregnancy and whether HSPs were associated with preterm birth in a secondary analysis of a prospective cohort with repeated biomarkers (N = 227 from MADRES). Serum HSPs were measured during early and late pregnancy using ELISA. Daily heat stress in the 30 days before HSP measurement was computed as Daily Maximum Heat Index (DMHI) and Wet Bulb Globe Temperature (WBGT). Distributed lag models identified sensitive windows of heat adaptation; logistic regression models assessed HSPs' effects on preterm birth (

Fields of Study & Subjects

Heat shock proteins research Climate Change and Health Impacts Effects of Environmental Stressors on Livestock

Publication details

Journal / source
Environmental Science & Technology
Publisher
American Chemical Society (ACS)
Volume
60
Issue
18
Pages
13323–13332
Publication date
1 May 2026
Language
EN