Bisphenol A and Its Substitutes Show Proatherosclerotic Potential through the Dysregulation of CD36-Driven Cholesterol Homeostasis
Abstract
mouse model, BPs exposure increased aortic plaque burden. These effects were significantly reduced or eliminated in CD36-silenced cells and mice. Interestingly, BPA substitutes exhibited more potent effects than BPA itself. Molecular docking further supported the direct interaction between BPs and CD36, as well as the structure-toxicity relationship trend of these BPs. Overall, the findings suggest that BPs promote CD36-mediated lipid accumulation and the development of atherosclerosis. The study highlights the need to reevaluate the safety of BPs and provides a foundation for risk assessment and prevention strategies related to BPs exposure and cardiovascular disease.
Fields of Study & Subjects
Effects and risks of endocrine disrupting chemicals
Mangiferin and Mango Extracts
Health
Environment
Cognitive Aging
Publication details
- Journal / source
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Volume
- 60
- Issue
- 22
- Pages
- 15616–15627
- Publication date
- 30 April 2026
- Language
- EN