A Structure-Informed Framework for Assessing Placental Transfer and Fetal Exposure of Emerging Chemicals:Insights from a Homologous Series of Alkylimidazolium Ionic Liquids

Environmental Science & Technology 2026

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Authors: Ming Li, Qing Yang, Shiwen Li, Shizhen Meng, Xiaole Zhao, Qiao Wang, Zhiyong Gong, Jingguang Li, Xin Liu, Y I Wu
DOI: 10.1021/acs.est.6c03276
Cited by: 1
References: 63

Abstract

< 0.01). Collectively, these results demonstrate that AM-ILs traverse the placenta via combined mechanisms of chain-length-driven passive diffusion and active transporter-mediated transport. Overall, these findings advance a mechanistic, structure-informed paradigm for predicting placental selectivity, enabling systematic assessment of fetal exposure risks across chemically diverse emerging contaminants.

Fields of Study & Subjects

Ionic liquids properties and applications Health Environment Cognitive Aging Per- and polyfluoroalkyl substances research

Publication details

Journal / source
Environmental Science & Technology
Publisher
American Chemical Society (ACS)
Volume
60
Issue
25
Pages
17742–17755
Publication date
8 June 2026
Language
EN