Generative AI as an Enabler for Process Intensification

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Authors: Alejandro Montesinos-Castellanos, Antonio Flores‐Tlacuahuac, Enrique A. López Guajardo, Karla M. Esquivel-Ortiz, R. Morales-Menendez
Cited by: 1
References: 79

Abstract

The advancement and fusion of the value chain, the industrial Internet of Things, big data with advanced analytics, and cloud computing have propelled the adoption of artificial intelligence (AI) in the design and evaluation of Process Intensification (PI), producing better results. Generative AI (GenAI) is an approach capable of generating new content with the proper database. The role of GenAI in the design of PI systems under the vision of Industry 4.0 (PI4.0) was explored. This study identified three primary categories of enablers critical to improving physical performance, digital capabilities, and strategic integration within PI4.0 systems. A brief review identified the potential of different GenAI models in PI4.0; however, through an in-depth case study (distillation column design), the GenAI application in the design of PI4.0 was shown to enable the creation of additional data and scenarios, foster increased creativity and exploration, introduce novel configurations and designs, and accelerate the pace of innovation. The results of the case study highlight the limitations of discriminative AI models and underscore the transformative potential of GenAI approaches. The most significant advantage of GenAI is its ability to expand the range of possibilities, making the PI4.0 design faster, more adaptable, innovative, and robust.

Fields of Study & Subjects

Process Optimization and Integration Business Process Modeling and Analysis Fault Detection and Control Systems

Publication details

Journal / source
Industrial & Engineering Chemistry Research
Publisher
American Chemical Society (ACS)
Volume
65
Issue
6
Pages
3389–3405
Publication date
9 February 2026
Language
EN