Utilization of Cooperative Ni Catalyst for Selective Transfer Hydrogenation of N-Heteroarenes with Minimal Hydrogen Surrogate
Abstract
Abstract Herein, an air-stable cooperative Ni(II)-NNN catalyst (1) bearing a bis(2-hydroxy pyridine) ligand was synthesized for the selective transfer hydrogenation of quinoline derivatives to 1,2,3,4-tetrahydro derivatives utilizing minimal loading of Me2NHBH3 as a hydrogen surrogate via a borylated product intermediate. Mechanistic studies include the identification of catalytically relevant deprotonated intermediate 1a, which sheds light on the hydride and proton transfer to the quinoline derivatives via the participation of the functionalized protic ligand arm.
Fields of Study & Subjects
Asymmetric Hydrogenation and Catalysis
Organometallic Complex Synthesis and Catalysis
N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Publication details
- Journal / source
- Inorganic Chemistry
- Volume
- 65
- Issue
- 25
- Pages
- 13745–13750
- Publication date
- 16 January 2026
- Language
- EN