Discovery of Imidazo[1, 2- a ]pyridine Hydrazone Derivatives as Novel Antifungal Tubulin-Targeting Agents via a Scaffold-Hopping Strategy

Journal of Agricultural and Food Chemistry 2026

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Authors: Yu Long, Zhou‐Qing Long, Yuanyuan Wu, Mei Li, Long‐Fei Li, Xian-Qun Hu, Xin-Ming Yang, L Y Zhang, Hong‐Wu Liu, Xiang Zhou, Zhenhua Li, Song Yang
DOI: 10.1021/acs.jafc.5c12629
Cited by: 3
References: 56

Abstract

formed multiple hydrogen bonds and π-π interactions with tubulin, and further induced intracellular microtubule aggregation, thereby disrupting both hyphal morphology and cellular architecture. This study provides strong evidence for structural diversification in tubulin-targeting antifungal agents, offering new perspectives for overcoming existing limitations in antifungal therapy.

Fields of Study & Subjects

Synthesis and biological activity Synthesis and Reactivity of Heterocycles Cyclization and Aryne Chemistry

Publication details

Journal / source
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Volume
74
Issue
22
Pages
16897–16910
Publication date
29 May 2026
Language
EN