Novel Approach in the Synthesis of Some Pyrimidines with Eminent Toxicological Effects towards Aphis gossypii ( Glover , 1887) and Outstanding Safety against Earthworms ( Aporrectodea caliginosa )
Abstract
This study reports the synthesis and bioevaluation of ten novel pyranothiazolopyrimidine derivatives. Their insecticidal efficacy against Aphis gossypii ( Glover, 1887) revealed compounds 3 and 10 as lead candidates, exhibiting toxicity comparable to the commercial standard acetamiprid insecticide. Notably, these compounds demonstrated a markedly safer ecotoxicological profile toward the earthworms ( Aporrectodea caliginosa ), with LC 50 values orders of magnitude higher than acetamiprid over 5- and 10-day exposures. Application also induced measurable changes in soil chemistry. These findings identify compounds 3 and 10 as promising insecticidal agents that combine potent aphid toxicity with significantly reduced nontarget risk, highlighting their potential for further development.
Fields of Study & Subjects
Advanced Synthetic Organic Chemistry
Organic Chemistry Synthesis Methods
Fungal Plant Pathogen Control
Publication details
- Journal / source
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 74
- Issue
- 8
- Pages
- 6683–6693
- Publication date
- 19 February 2026
- Language
- EN