Linear Peptidomimetics Containing Isoxazoline Scaffold: Design, Synthesis, Bioevaluation as Efficient Insecticidal Agents

Journal of Agricultural and Food Chemistry 2026

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Authors: Junkun Ren, Zhigang Zhang, Liqiao Shi, Hexiang Wang, Yufei Wang, Ruoheng Jin, Wei Fang, Quanjie Xia, Xinsheng Wang, Longzhu Bao, Tong Long, Yan Gong
+2 more Ling Zhao, Shaoyong Ke
DOI: 10.1021/acs.jafc.5c16699
Cited by: 1
References: 39

Abstract

showed outstanding performance, achieving 100% mortality against L0 and L1 larvae at 0.195 μg/mL and demonstrating higher activity than that of Chlorantraniliprole. Density functional theory (DFT) calculations and molecular docking studies suggested that these compounds may possess strong binding affinity to the γ-aminobutyric acid (GABA) receptor, indicating their potential as novel GABA receptor inhibitors for the integrated management of lepidopteran pests in agriculture.

Fields of Study & Subjects

Chemical Synthesis and Analysis Biochemical and Structural Characterization Click Chemistry and Applications

Publication details

Journal / source
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Volume
74
Issue
19
Pages
14873–14885
Publication date
9 May 2026
Language
EN