Oral Exposure to Polypropylene Microplastics Exacerbates Cow’s Milk Allergy in a Murine Model by Skewing the DCs/T-Cell Response toward Th2 Polarization

Journal of Agricultural and Food Chemistry 2026

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Authors: Qiang Shi, Zhongliang Wang, Haojie Luo, Chuang Chen, Yan Chen, Xin Li, Yanhai Xie, Shuangyan Zheng, Xuanyi Meng, Yong Wu, Jinyan Gao, Hongbing Chen
DOI: 10.1021/acs.jafc.6c00965
Cited by: 2
References: 43

Abstract

DCs/T-cell coculture system confirmed that PP enhanced antigen uptake by DCs and shifted naïve T-cell differentiation toward Th2 polarization, eventually aggravating CMA susceptibility. This study highlighted the potential health risk posed by NMPs contamination in food and suggested a possible contribution to the escalating prevalence of CMA in infants.

Fields of Study & Subjects

Microplastics and Plastic Pollution biodegradable polymer synthesis and properties Effects and risks of endocrine disrupting chemicals

Publication details

Journal / source
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Volume
74
Issue
15
Pages
12461–12474
Publication date
9 April 2026
Language
EN