Chiisanogenin Targets MLKL to Restore Autophagy and Suppress Pyroptosis in Renal Ischemia-Reperfusion Injury

Journal of Agricultural and Food Chemistry 2026

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Authors: Shurong Qu, Yuxin Yang, Xiaofeng Liu, Zhenming Yu, Haijing Wang, Yan Zhao, Hongbo Teng
DOI: 10.1021/acs.jafc.6c02315
Cited by: 1
References: 45

Abstract

models confirm that chiisanogenin attenuates IRI-induced acute damage and retards the AKI-to-CKD fibrotic transition. These findings highlight chiisanogenin as a promising therapeutic candidate for treating ischemic renal injury.

Fields of Study & Subjects

Inflammasome and immune disorders Autophagy in Disease and Therapy Gout Hyperuricemia Uric Acid

Publication details

Journal / source
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Volume
74
Issue
22
Pages
17099–17128
Publication date
2 June 2026
Language
EN