Novel N ′-Phenyl Benzyl Carbazate Derivatives with Potent Multiple Antifungal Activity: Design, Structure–Activity Relationship, and Action Mode
Abstract
The development of new fungicides has been a requirement for agricultural production, food safety, and the advancement of pesticides. In this study, 30 N ′-phenyl benzyl carbazates were designed through the fusion of multiple antifungal pharmacophores to find promising fungicide candidates. Twenty-six compounds exhibited average EC 50 values of 0.316–4.617 μg/mL against six phytopathogenic fungi, superior to carbendazim and boscalid against half or more of the fungi. Half of the compounds displayed average EC 50 values of
Fields of Study & Subjects
Synthesis and biological activity
Fungal Plant Pathogen Control
Antifungal resistance and susceptibility
Publication details
- Journal / source
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 74
- Issue
- 22
- Pages
- 17500–17510
- Publication date
- 1 June 2026
- Language
- EN