Rediscovering Diazaborines: Synthesis and Bioactivity Profiling of Boron-Containing FabI Inhibitors against Gram-Negative Bacteria

Journal of Medicinal Chemistry 2026 Open access

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Authors: Polina Ilina, Vladimir Iashin, Cristina Durante Cruz, Juho Heininen, Iiro Järvi, Inna Pönniö, Sami Heikkinen, Pauli Johan Wrigstedt, Léo Ghemtio, Karina Moslova, Henri Xhaard, Paula S. Kiuru
+2 more Jesús Perea-Buceta, Päivi Tammela
DOI: 10.1021/acs.jmedchem.5c01766
Cited by: 1
References: 42

Abstract

infection at the therapeutic dose of 1.13 and 2.81 mg/kg, demonstrating efficacy similar to ciprofloxacin.

Fields of Study & Subjects

Organoboron and organosilicon chemistry Antimicrobial agents and applications Microbial Natural Products and Biosynthesis

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
4
Pages
3796–3810
Publication date
7 February 2026
Language
EN