Novel 2-(2′-Benzothiazolyl)-benzimidazole-Based Iridium(III) Photocatalysts Exhibit Antiproliferative Effects in 2D and 3D Cancer Cells to Bypass Hypoxia-Induced Resistance

Journal of Medicinal Chemistry 2026 Open access

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Authors: Antonio Linero-Artiaga, Marie Svitelova, Vojtěch Novohradský, Venancio Rodríguez, Lenka Marková, Jana Kasparkova, Christoph Janiak, J. Ruiz, Viktor Brabec
DOI: 10.1021/acs.jmedchem.5c03280
Cited by: 2
References: 92

Abstract

demonstrated deep tissue penetration sought to overcome PDT limitations in solid tumors. Overall, the synthesized complexes showcase high efficacy and favorable pharmacological profiles, positioning them as promising candidates for the ROS-guided photodynamic treatment of cancers, including those located within hypoxic environments.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Cancer Hypoxia and Metabolism Click Chemistry and Applications

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
6
Pages
6991–7011
Publication date
16 March 2026
Language
EN