Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable, Low-Aggregating, and Highly Efficacious Antibody-Drug Conjugates

Journal of Medicinal Chemistry 2026

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Authors: Ryan V. Quiroz, Simon B. Lang, Rebecca Johnson, Nancy Zepeda, Vlad Bacauanu, Christian L. Morales, Manoj B. Charati, John A. Flygare, Olivia R Chastain, Zhong L. Hua, Edward P. Bowman, Bernhard H. Geierstanger
+14 more Alycia K Uyeoka, Fan Zhang, Huimin Zhong, Esther Kofman, Daniela M. Tomazela, Laurence Fayadat‐Dilman, Mengxuan Jia, Michael Judo, Ian W. Knemeyer, Peyman Akbari, Qingyun Yan, Evan R. Barry, Alan B. Northrup, W Michael Seganish
DOI: 10.1021/acs.jmedchem.5c03706
Cited by: 1
References: 46

Abstract

. These linker-payloads are promising new leads for the treatment of cancer and represent a generalizable, modular, and advantageous linker platform.

Fields of Study & Subjects

HER2/EGFR in Cancer Research Advanced Biosensing Techniques and Applications Radiopharmaceutical Chemistry and Applications

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
9
Pages
9928–9951
Publication date
30 April 2026
Language
EN