Discovery of LT-1339–553 as a Potent RIPK1 Inhibitor for Schistosomiasis-Induced Hepatic Fibrosis

Journal of Medicinal Chemistry 2026

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Authors: Ju-Lu Lu, Qin-Di He, Yi-Han Yang, Jingping Li, Si-Rui Mo, 梁力, Ya-Qi Zhang, Si-Ming Jia, Zi-Tian Cheng, Jie Cheng, 杨沛, Hong-Mei Li
+4 more Tao Lu, Yuehua Chen, Li-Jun Song, Shuai Lü
DOI: 10.1021/acs.jmedchem.5c03775
Cited by: 1
References: 46

Abstract

as a promising candidate for the treatment of hepatic fibrosis.

Fields of Study & Subjects

Parasites and Host Interactions Liver physiology and pathology Cell death mechanisms and regulation

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
10
Pages
12069–12098
Publication date
16 May 2026
Language
EN