Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast Cancer

Journal of Medicinal Chemistry 2026

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Authors: Yaxin Teng, Linyu Yang, Haoyue Luo, Minghai Tang, Jialing Song, Liping Gou, Yuzhou Xiao, Xue Cui, Tao Yang, Xiaobo Cen, Lijuan Chen, Yong Li
+2 more Yinglan Zhao, Zhuang Yang
DOI: 10.1021/acs.jmedchem.5c03804
Cited by: 3
References: 38

Abstract

validation for USP1-PARP inhibitor combination therapy in TNBC.

Fields of Study & Subjects

PARP inhibition in cancer therapy Advanced Breast Cancer Therapies Cancer Treatment and Pharmacology

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
9
Pages
10594–10620
Publication date
29 April 2026
Language
EN