Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease Models

Journal of Medicinal Chemistry 2026 Open access

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Authors: Cynthia D. Jesudason, Claudia Rangel-Barajas, Colin J Beach, Daniel E. Beck, Isaac H. Caballero-Floran, W Brent Clayton, Lais Da Silva, Juliane C David, Suzanne Doolen, Alexandra N Faulkner, Adam K Hamdani, Hasi Huhe
+23 more Kevin Huynh, Ryan D. Imhoff, June Javens-Wolfe, Emily R Mason, Mustapha Moussaif, Kratika Singhal, Disha M. Soni, Matilda van Buuren-Milne, Sean-Paul Williams, Steven P. Angus, Shaoyou Chu, Jeffrey L Dage, Philip A. Hipskind, Travis S. Johnson, Rima Kaddurah-Daouk, Bruce T Lamb, Peter J Meikle, Andrew D. Mesecar, Alan David Palkowitz, Sara K. Quinney, Stacey J Sukoff Rizzo, Adrian L Oblak, Timothy I Richardson
DOI: 10.1021/acs.jmedchem.6c00010
Cited by: 1
References: 82

Abstract

resulted in brain exposure sufficient to alter gene expression and reduce IL-1β levels as pharmacodynamic markers of microglial activation and neuroinflammation in an amyloidosis mouse model of Alzheimer's disease.

Fields of Study & Subjects

Alzheimer's disease research and treatments Protein Tyrosine Phosphatases Melanoma and MAPK Pathways

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
9
Pages
10734–10763
Publication date
30 April 2026
Language
EN