Design, Synthesis and Biological Evaluation of 6H-Benzimidazo[1′,2′:1,2]pyrido[3,4- b ]indole Derivatives as TDP1 Inhibitors: Potent Synergistic Agents with Topotecan against Cervical Cancer

Journal of Medicinal Chemistry 2026

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Authors: Huang Zeng, Bo Qiu, Jiunlong Yang, Yuman Xie, Hui Huang, Shengyuan Zhang, Hua Nie, Nan Wang, Zeyong Huang, Lingfeng Wu, Jiayao Liu, Xuerou Zheng
+2 more Yuanbei Zhuang, Hao Cheng Yang
DOI: 10.1021/acs.jmedchem.6c00016
Cited by: 1
References: 40

Abstract

as a promising TDP1 inhibitor with potential to enhance TPT-based therapy.

Fields of Study & Subjects

Cancer therapeutics and mechanisms Synthesis and Biological Activity Chemical Reactions and Isotopes

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
9
Pages
10788–10810
Publication date
21 April 2026
Language
EN