Identification of XZ8078 as a Dual-Target Degrader Targeting PARP1 and IKZF3 for Broad Spectrum Anticancer Treatment

Journal of Medicinal Chemistry 2026

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Authors: Xi Zhang, Jing He, Yaoyao Li, Xubin Bao, X Wang, Ze‐Hong Miao, Chang‐Yun Wang, Zhiqing Liu, Jin-Xue He, Pingyuan Wang

DOI: 10.1021/acs.jmedchem.6c00239

Cited by: 1

References: 53

Abstract

may be a powerful therapeutic agent not only for treating PARPi-sensitive tumors but also PARPi-resistant tumors, even HR-proficient tumors.

PARP inhibition in cancer therapy Telomeres Telomerase and Senescence Nuclear Structure and Function

References 53