S-Nitrosation-Based Target Discovery and Drug Development: Toward a Nitric Oxide Drug 2.0 Paradigm
Abstract
Protein S-nitrosation (SNO) has emerged as a regulatory mechanism of nitric oxide (NO) signaling as important as the classical sGC/cGMP axis. Herein, we discuss recent advances that redefine SNO as an orchestrated, enzyme-modulated redox signal with therapeutic implications. We highlight the identification of the SCAN enzyme as a transnitrosylase, disease-associated SNO targets revealed through proteomic studies, and evolving pharmacological strategies─from global SNO modulation to protein- and site-specific interventions. Emerging platforms such as SNOTAC and warhead exemplify a "Nitric Oxide Drug 2.0" paradigm, enabling precise redox modulation for targeted drug discovery.
Fields of Study & Subjects
Nitric Oxide and Endothelin Effects
Neutrophil
Myeloperoxidase and Oxidative Mechanisms
Metal-Catalyzed Oxygenation Mechanisms
Publication details
- Journal / source
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 69
- Issue
- 3
- Pages
- 2002–2005
- Publication date
- 1 February 2026
- Language
- EN