Structure-Guided Discovery of Potent, Selective, and Orally Bioavailable Werner Syndrome RecQ Helicase Inhibitors for the Treatment of Microsatellite Instability-High Tumors

Journal of Medicinal Chemistry 2026

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Authors: Qibang Sui, Dan Wang, Hui Hou, Chen Shi, Xiaoying Cai, Yuanyang Zhou, Rongrong Cui, Manjia Li, Jia Liu, Dan Teng, Chong Qin, Sulin Zhang

+1 more

Mingyue Zheng

DOI: 10.1021/acs.jmedchem.6c00331

Cited by: 1

References: 22

Abstract

as a promising WRN inhibitor candidate for the treatment of MSI-H tumors.

DNA Repair Mechanisms Mitochondrial Function and Pathology Microtubule and mitosis dynamics

References 22