Structure-Based Discovery of Imidazo[4,5- c ]pyridine SARM1 Modulators Showing Paradoxical Activation

Journal of Medicinal Chemistry 2026

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Authors: Steven K. Albanese, Brittany E. Hopkins, Andrea M. Olland, Alexis Fairman, Nadim S. Shaikh, Shulu Feng, Mahesh Thakkar, Andreas Verras, Alexey Dementiev, Ward G. Walkup, Christian Atsriku, Harathi D. Srinivas
+14 more Wayne Allen, Khuram Ashraf, Pieter H. Bos, Peng Hsiao, Kyle G. Kroeck, Zhijian Liu, Anu Nagarajan, Christopher T. Szlenk, Mats Svensson, Zachary Lee Johnson, Kanishk Kapilashrami, Stephen J. Rubino, Andrew Kaplan, Adam M. Levinson
DOI: 10.1021/acs.jmedchem.6c00352
Cited by: 1
References: 28

Fields of Study & Subjects

Pharmacological Receptor Mechanisms and Effects Ion Channels and Receptors Calcium signaling and nucleotide metabolism

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
8
Pages
9521–9536
Publication date
8 April 2026
Language
EN